- Rohit Jaimini Dr. Manish Jaimini
- Maharishi Arvind University, Mudiaramsar, Jaipur, Raj., Pin-302041
- DOI:Â https://doi.org/10.61280/journalmedicinalplants.v1i1.171
Keywords:
Gastro-Retentive Time, Polymer, Bioavailability, Buoyancy, Floating Time, Narrow Absorption, Short Half Life, Low Aqueous Soluble, Acid Stable Drugs
Abstract
The background of this review is to provide the information about the current state and innovation of gastro retentive drug delivery system leading with the future perspective to overcome the limitation of gastro retentive drug delivery system. In this context, a number of gastro retentive drug delivery systems have been employed to increase the therapeutic effectiveness of drugs with a limited window of absorption, unstable at alkaline pH, solubility in acidic conditions, and local stomach activity. The goal of this review was to study, compile, and concisely describe both new and older literatures, with a particular focus on strategies that are currently being used to extend gastric residency duration for narrow absorption, acidic (stable in stomach) but unstable at basic pH low aqueous solubility, short biological half life drugs to enhance bioavailability, patient compliance by decreasing side effects of drugs by use reduced dose of drug. The importance of in-vitro and in-vivo evaluation parameters of the various gastro retentive drug delivery systems, as well as their applications, is outlined. Future perspectives on this technology are also covered, including a brief discussion of the classification, formulation considerations for gastro retentive drug delivery systems, factors that control gastric retention, advantages, drawbacks, and applications of gastro retentive drug delivery systems to reduce the gastric emptying rate in both fasted and fed states. Overall, the formulation scientists who are designing the gastro retentive drug delivery systems may find this review useful and instructive.